Lithoplocamia lithistoides
Web1 nov. 2024 · Plocabulin, a marine natural polyketide isolated from the sponge Lithoplocamia lithistoides, is a novel and potent microtubule-destabilizing agent. … WebPM050489 is an effective polyketone inhibitor of Microtubule/Tubulin that can be isolated from Madagascan sponge Lithoplocamia lithistoides. PM050489 inhibits mitosis with an IC50 value of 26.4 nM. PM050489 has antitumor activity and can be used in cancer research [1] [2] . PM050489 inhibits the activity of HT-29, A-549 and MDA-MB-231 cells ...
Lithoplocamia lithistoides
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Web21 jul. 2024 · Sponge: Lithoplocamia lithistoides PM060184 C 31H 45N 3O 7 Inhibits tubulin polymerization, which reduces microtubule dynamicity, and inhibits cell migration (),,,, Natural Products of Marine Origin for the Treatment of Colorectal and Pancreatic Cancers: Mechanisms and Potential ... WebLithoplocamia lithistoides adalah spesies spons yang tergolong dalam kelas Demospongiae. Spesies ini juga merupakan bagian dari genus Lithoplocamia dan famili …
http://pharmabiz.com/NewsDetails.aspx?aid=93751&sid=2 WebGlobal Biodiversity Information Facility. Free and Open Access to Biodiversity Data.
Web21 jan. 2024 · Kahalalide F has displayed potent cytotoxicity against cancer cells of the breast (BT-474, MCF7, MDA-231, and SK-BR-3), colon (HT29 and LoVo), liver (Hep G2), lung adenocarcinoma (A549), ovaries,... Webde Voogd, N.J.; Alvarez, B.; Boury-Esnault, N.; Carballo, J.L.; Cárdenas, P.; Díaz, M.-C.; Dohrmann, M.; Downey, R.; Hajdu, E.; Hooper, J.N.A.; Kelly, M.; Klautau ...
Web17 mrt. 2024 · Plocabulin (PM060184/PM184, PharmaMar) is a compound of marine origin derived from the Madagascan sponge Lithoplocamia lithistoides. Plocabulin belongs to a family of tubulin-binding agents that inhibits tubulin polymerization by binding to the dimer’s end, with one of the highest known affinities among tubulin-binding agents.
Web7 dec. 2024 · Plocabulin (PM184; Fig. 8) and its chloro-derivative (Fig. 8; PM-050489) were isolated by PharmaMar scientists from the sponge Lithoplocamia lithistoides, but due to the low levels in the extract, both … great leaders of the christian churchWebOvarian cancer (OC) is a life-threatening tumor and the deadliest among gynecological cancers in developed countries. First line treatment with a carboplatin/paclitaxel regime is initially... great leaders serveWebIsolation of PM050489 (1): The frozen specimen of Lithoplocamia lithistoides(61 g), collected by hand using SCUBA diving in Madagascar (S 17º 06.071' / E 49º 51.385') at a depth ranging between 6 and 20 m, was diced and extracted with H2O (3 x 200 mL) and then with a mixture of MeOH:CH2Cl2 (50:50, 3 x 200 mL) at 23 ºC. great leaders of tamil naduWeb1 nov. 2024 · Plocabulin, a marine natural polyketide isolated from the sponge Lithoplocamia lithistoides, is a novel and potent microtubule-destabilizing agent. Guided by the reported binding mode, several new analogs of plocabulin have been designed through removing the right aliphatic chain and further modifying on the group and the … flogas leicestershireWeb10 jul. 2013 · Paclitaxel is arguably the most well-known and commercially successful mitosis inhibitor; intriguingly, these new compounds isolated from the Madagascan sponge Lithoplocamia lithistoides show a distinct biochemical mechanism of … great leaders of philippinesWebLithoplocamia is een geslacht van sponsdieren uit de klasse van de Demospongiae . For faster navigation, this Iframe is preloading the Wikiwand page for Lithoplocamia . Home great leaders show vulnerabilityWebOriginally isolated from the Madagascan marine sponge Lithoplocamia lithistoides, plocabulin is now obtained by total synthesis [3]. Plocabulin binds tubulin with high a nity, reducing its polymerization and depolymerization to a similar extent and thereby inhibiting microtubule dynamicity (Figure1) [4–6]. flogas live chat